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FDA modules are currently available for the prediction of human toxicity!
For selected end points of human toxicity we obtain exactly the same result as the U.S. Food and Drug Administration (FDA), which is responsible for pharmaceutical approvals, since we can use the same software and data records.
Deadlines for the registration of chemicals under REACH:

2008-06-01 - 2010-12-01: Chemicals > 1000 t/a, CMR chemicals
(Categ. 1/2)> 1 t/a

Chemicals with R50/53 > 100 t/a

2008-06-01 - 2013-06-01: Chemicals > 100 t/a to 1000 t/a
2008-06-01 - 2018-06-01: Chemicals > 1 t/a to 100 t/a

Further information at:

European Chemical Agency (ECHA): http://echa.europa.eu

Candidate lists for particularly alarming materials published by the European chemical agency ECHA,

SVHC: substances of very high concern

For articles with more than 0.1 mass percent of SVHC, the manufacturer, importer or user is obligated to inform his purchaser

SVHC list:
http://echa.europa.eu/consultations/authorisation/svhc/svhc_cons_en.asp

K. Kümmerer, Benign by Design: Sustainable from the very beginning:
Rational design of molecules by life cycle engineering as an important
approach for green pharmacy and green chemistry. Green Chem. 9, 899-907, 2007,
http://www.rsc.org/Publishing/Journals/GC/article.asp?doi=b618298b

Pharmaceutical and Chemical Development:
The reduction of environmental contamination by means of targeted molecule design / environmental sciences and hazardous chemical research/2008, *20*(4), 249 K. Kummerer, E. Schramm*DOI: *10.1007/s12302-008-0021-5

http://www.springerlink.com/content/j667g4277211m041/